Development and evaluation of analytical - Diva Portal
2015-04-23 Urine metabolic profiling combined with LC/QTOF-MS was used to find and identify the metabolites of dextromethorphan, a common over-the-counter (OTC) cough suppressant .Chromatograms of both blank urine and urine taken 4 h after ingestion of dextromethorphan were compared using Mass Profiler software.The software first analyzes all groups of ions (known as features) in the chromatogram of **AS-IS, Untested, due to price / age.** Waters QTOF Premier Mass Spectrometer. System Includes: Waters QTOF Premier MS Computer Cables and connectors. The Waters QTOF Premier Mass Spectrometer is the next generation exact mass platform for the Pharmaceutical, Biotechnology and Life Science industries. Quadrupole-time-of-flight (QTOF) mass spectrometers are high mass accuracy and high resolution instruments ideal for peptide sequencing in the Information Dependent Acquisition (IDA) mode. Their high resolution is useful for determination of charge state and protein mass measurements in addition to accurate mass determination of biological compounds. The price difference between Exactive+ and QExactive+ is around $10K, which is less then 5% of the instrument price. The largest detection mass range is 20 - 10000 Da. But the price of this kind of MS is very high.
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Therefore, this study aims to investigate the protective effects of hydrogen on stroke-induced ischemia–reperfusion injury History of LC-MS. The coupling of chromatography with MS is a well developed chemical analysis strategy dating back from the 1950s. Gas chromatography (GC)–MS was originally introduced in 1952, when A. T. James and A. J. P. Martin were trying to develop tandem separation - mass analysis techniques. Agilent LC-MS QTOF. II. Scope and Implementation: This SOP applies to Agilent LC-MS QTOF instrument located in the Life Sciences Research Building, room LS1151. III. Introduction: The Agilent 6530B Accurate Mass Quadruple Time-of-Flight mass spectrometer is equipped with dual electrospray ionization source and an Agilent 1260 UPLC liquid Agilent 6500 Series Q-TOF LC/MS Maintenance Guide 13 Basic Operation 1 Starting and Shutting Down Starting and Shutting Down This section describes how to start up your Q-TOF LC/MS and how to shut it down.
COVER ALL BASES WITH MALDI/LCMS COMBINED
Price: Please Inquire. Condition: Refurbished.
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View Details + Add to List. Agilent 6460C (6470, 6490, 6495) QQQ Triple Quadrupole LC/MS-MS #36963. When it comes to selecting a GC-MS system, budget is obviously one key consideration.
The Global Q-TOF Mass Spectrometry Market is estimated to be USD 872.4 Mn in 2020 and is expected to reach USD 1270.5 Mn by 2025, growing at a CAGR of 7.8%.Market DynamicsMajor factors that drive
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This is without a doubt the best QTOF Mass Spectrometer on campus. Instrument characteristics include: LC pumps can handle up to 8000 psi; MS and MS/MS on the fly; Mass Range of up to 10,000 Daltons (singly-charged) Sensitive, Accurate-Mass MS and MS/MS Analyses The Agilent 6530 Accurate-Mass Q-TOF LC/MS system is designed to provide superior data quality and advanced analytical capabilities for profiling, identifying, characterizing, and quantifying low molecular-weight compounds and biomolecules with confidence. The 6530 Q-TOF LC/MS is an entry-level Q-TOF that enables accurate-mass spectrometry for more analytical confidence compared to unit resolution systems. Full MS spectra followed by MS/MS or All Ions acquisition enables applications in pharmaceutical and life science industry, as well as government agencies. Xevo G2-XS Tof Time-of-Flight Mass Spectrometry Xevo G2 XS Tof is a benchtop Time of flight MS combining StepWave ion optics, XS Collision Cell and QuanTof technology for superior robustness, sensitivity and selectivity, resulting in high quality, comprehensive qualitative and quantitative information.
Available from KRSS, Agilent 6520 Accurate Mass Q-TOF LC/MS system with Agilent HPLC 1200
The Agilent LC-MS 6550 iFunnel Q-TOF is a high resolution system well suited High data acquisition rates of up to 50 spectra/second allow for maximum data
“This unit is sold as-is, untested.” Price: US $14,999.99. Rates at a glance: KU Lawrence Campus Open access ESI TOF or GC/MS with EI ionization And ESI infusion MS or MS/MS on the QTof or Ultima QQQ (by
Thermo Scientific ScreenID HRAM LC-MS Mass Spectrometry SystemAsk Price. Model Name/Number: ScreenID HRAM. Brand: Thermo Scientific. For Use With:
30 Sep 2014 “In the past, lower cost GC/SQ (single Quadrupole) MS dominated many food safety labs, but the limited selectivity of unit-mass resolution MS
28 Jul 2014 With quadrupole time-of-flight mass spectrometry featuring QuanTof technology, the Xevo G2-XS QTof MS delivers the highest quality, most
MS Vision offers flexible and cost-effective service, ensuring maximum performance and uptime of a wide range of mass spectrometry and LC systems. 13 Nov 2014 UPLC-Q-ToF-MS data was enhanced by the alignment of exact mass data from FTICR-MS, and marker peaks were identified using
Orbitrap does not have MS/MS capability (please correct me if I am wrong).
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The X500B QTOF System is purpose built for standard biotherapeutic characterization analyses while the X500R QTOF System offers robust qualitative and quantitative performance for food, environmental, and forensic workflows, or for metabolomic analysis. The impact II sets a technology standard for analytical performance in residue and contamination screening, forensics, industrial and synthetic chemistry, biomarker research, and more, with unparalled ultra-high resolution Qq-Time-Of-Flight mass spectrometry. Advances in Q-TOF LC/MS for Pharma Applications Figure 1:This analysis of a trace metabolite that co-elutes with the parent drug shows that next-generation Q-TOF LC/MS systems easily achieve a dynamic range of greater than five orders of magnitude. The figure shows a single spectrum from data obtained at 3.3 spectra per second.
Agilent’s GC-qTOF has a list price of about $375,000, Sheehan says, which is four-to-five times more than a single-quad system. But think also about application, he says. What kind of samples will you be working with, for instance? The LC system was connected to a Bruker Daltonics, maXis qTOF mass spectrometer equipped with an electrospray ion source operated in positive ion mode (Bruker Daltonics, Bremen, Germany).
Enass Salih — Helsingfors universitet
Manufacturer: Agilent Technologies Model: 6490A Condition: Used Warranty: 30 day Price: $119,000. View Details + Add to List. Agilent 6460C (6470, 6490, 6495) QQQ Triple Quadrupole LC/MS-MS #36963. When it comes to selecting a GC-MS system, budget is obviously one key consideration. Agilent’s GC-qTOF has a list price of about $375,000, Sheehan says, which is four-to-five times more than a single-quad system. But think also about application, he says. What kind of … Time-of-flight mass spectrometers (TOF MS) do exactly what their name suggests: determine an ion’s mass-to-charge ratio (m/z) based on how long it takes for that ion to travel down the instrument’s “flight tube” and reach the detector.
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Chromatography of pharmaceutical peptides - contrasting
Abstract:The ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS Qtof Ms Mass Spectrometer, supplied by Waters Corporation, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations.
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Mass Spectrometers LC/MS Systems. 30 day Price: $34,000. View Details. Agilent 6490A Triple Quadrupole with 1290 Infinity II UHPLC System #40892 Series Q-TOF LC/MS software to enable these advantages. The Agilent Accurate-Mass 6530 Q-TOF, the Agilent UHD Accurate-Mass 6540 Q-TOF LC/MS, and the Agilent 6550 iFunnel Q-TOF LC/MS systems are the only Q-TOF instruments that can use the Agilent Jet Stream Technology. The Agilent 6230 TOF LC/MS system is the only TOF that can use the The Global Q-TOF Mass Spectrometry Market is estimated to be USD 872.4 Mn in 2020 and is expected to reach USD 1270.5 Mn by 2025, growing at a CAGR of 7.8%.Market DynamicsMajor factors that drive Quite simply, Xevo QTof MS will be the best business decision you’ve ever made. New and used Waters Xevo QTof MS's for sale on LabX below.
A rapid, precise and accurate gradient UPLC method was developed for the selective separation of degradation products of alcaftadine. Forced degradation studies of the drug were carried out by examining factors suggested by ICH guidelines. The degradation products were formed in acidic, alkaline and peroxide conditions; however, the drug was stable in neutral, thermal and photolytic Categories: GC-TOF and GC-QTOF Home » Products » Mass Spectrometry » GC-TOF and GC-QTOF Time-of-flight mass spectrometers designed to achieve the best sensitivity and productivity, making qualitative and quantitative analyzes possible and easy to perform As a reductive gas, hydrogen plays an antioxidant role by selectively scavenging oxygen free radicals. It has been reported that hydrogen has protective effects against nerve damage caused by ischemia–reperfusion in stroke, but the specific mechanism is still unclear.